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What is ACCUTANE One of the most powerful treatments for severe cystic acne is a prescribed medicine called ACCUTANE. This drug was discovered in 1979, and it was used to treat patients with severe acne with successful (and lasting) results. Today, it is still the go-to treatment for severe acne that does not respond to retinol skin creams and antibiotics, as the results are fast, positive, and often permanent. ACCUTANE chemical composition resembles that of retinoic acid, a compound derived from Vitamin A. The primary application for ACCUTANE is for nodular acne in patients that do not respond to topical applications and standard antibiotic treatments.